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Title

Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: analysis of effectiveness using Scheimpflug imaging

Purpose	To evaluate changes in corneal keratometry, corneal elevation, and keratoconus indices after corneal collagen crosslinking with riboflavin and ultraviolet-A (UVA) light in eyes with progressive keratoconus.
Methods	38 eyes underwent corneal crosslinking with riboflavin and UVA irradiation. Scheimpflug imaging was performed preoperatively and at 1 week, 1, 3, and 6 months, and 1 year after crosslinking. Index of Surface Variance (ISV), Index of Vertical Asymmetry (IVA), Keratoconus Index (KI), Central Keratoconus Index (CKI), Index of Height Asymmetry (IHA), Index of Height Decentration (IHD), and Rmin (Smallest Radius of Curvature) were measured at each visit.
Results	Mean differences between postoperative and preoperative visits were as follows : K max +0.3 D, ISV +5.3, IVA +0.1, KI +0.1, CKI +0.0, IHA -4.1, IHD 0.0, Rmin 0.0. Mean follow-up was 185 days.
Conclusion	Stable anterior and posterior corneal curvatures, and stable keratometry indices indicate that keratoconus did not progress : the results indicate a probable long-term stabilization and improvement after collagen crosslinking. Thus, corneal collagen crosslinking is an effective therapeutical option for progressive keratoconus.

Author 1