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TitelOCT angiography of the retina detects a difference in peripapillary vessel density between dark and light adaptation.
DoelTo evaluate the effects of light and dark exposure on vessel density in the retinal and optic nerve head (ONH) regions, as measured using optical coherence tomography angiography (OCTA).
Methodes30 eyes of 30 healthy volunteers were examined using a high-speed and high-resolution spectral-domain OCT XR Avanti system with a split-spectrum amplitude de-correlation angiography algorithm. OCTA imaging was performed after dark adaptation and after exposure to light. The vessel density data of the superficial and deep retinal macular and optic nerve head region OCT-angiogram were analyzed for these two light conditions.
ResultatenThe mean patient age was 28.22 ± 4.95 years. The vessel density in the radial peripapillary layer of ONH in the light-adapted state was significantly higher when compared with the dark-adapted state (dark-adapted state: 59 ± 6.79, light-adapted state: 60.32 ± 5.93, p = 0.0206). Comparisons of other OCT-A measurements showed no significant differences.
ConclusiePeripapillary vessel density changes in response to light and dark exposure. OCTA allows in-vivo quantitative analysis of ONH perfusion and may provide a promising tool for analyzing neurovascular coupling in healthy subjects and in disease.
BelangenverstrengelingNee
Auteur 1
NaamNELIS
InitialenP
InstituutUKM, UZB (VUB)
StadMuenster, Brussels
Auteur 2
NaamMüller
InitialenV
InstituutUKM
StadMuenster
Auteur 3
NaamAlnawaiseh
InitialenM
InstituutUKM
StadMuenster
Auteur 4
NaamMihailovic
InitialenN
InstituutUKM
StadMuenster
Auteur 5
NaamEter
InitialenN
InstituutUKM
StadMuenster
Auteur 6
NaamTen Tusscher
InitialenM
InstituutUZB (VUB)
StadBrussels
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