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This abstract is assigned to session Poster session in O'Bistro
Presentation typeOB - oral
TitleRetinal oxygen metabolism in healthy subjects and glaucoma patients
PurposeTo study the role of ischemia/hypoxia in the pathophysiology of glaucoma in a prospective, clinical trial.
MethodsThis was a 2 centre study where retinal vessel oxygen saturation was measured in glaucoma patients and healthy individuals with a non-invasive spectrophotometric retinal oximeter. Visual fields were obtained in the glaucoma patients. Statistical analysis was performed using a Student’s t-test.
ResultsNo statistical difference was found in retinal oxygen saturation in arterioles (p=0.16), in venules (p=0.12) and arteriovenous difference (AV) (p=0.39) whenglaucoma patients (n=74) were compared to healthy individuals (n=89). However, when patients with advanced glaucoma (visual field mean defect (MD≤-10dB, n=21) were compared to healthy individuals, the oxygen saturation in venules was higher (58%±5% vs. 54%±6%; p=0.005, mean ± standard deviation (SD)) and the AV difference was lower (36±5% vs. 40%±6%; p=0.02). In glaucoma patients with mild glaucoma (MD≥-5dB, n=33), compared to healthy individuals, no statistical differences were found in retinal oxygen saturation (p=0.26-0.99).
ConclusionGlaucoma patients with severe glaucoma have higher oxygen saturation in venules and lower AV difference in oxygen saturation compared to healthy individuals. No difference is found between healthy individuals and glaucoma patients with mild visual field defects. The decreased AV difference in severe glaucoma may be related to lower oxygen consumption resulting from tissue atrophy in the retina.
Authors 1
Last nameVANDEWALLE
InitialsE
DepartmentUZLeuven
CityLeuven
Authors 2
Last nameOlafsdottir
InitialsOB
DepartmentUniversity of Iceland
CityReykjavik
Authors 3
Last namePinto
InitialsLA
DepartmentLisbon University
CityLisbon
Authors 4
Last nameStalmans
InitialsP
DepartmentUZLeuven
CityLeuven
Authors 5
Last nameVan Calster
InitialsJ
DepartmentUZLeuven
CityLeuven
Authors 6
Last nameZeyen
InitialsT
DepartmentUZLeuven
CityLeuven
Authors 7
Last nameStefánsson
InitialsE
DepartmentUniversity of Iceland
CityReykjavik
Authors 8
Last nameStalmans
InitialsI
DepartmentUZLeuven
CityLeuven
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