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Title

The EVRS Macular Edema Study

Purpose	To determine the efficacy of different treatment options in macular edema (ME) of numerous etiologies.
Methods	A retrospective multicenter study including 2603 patients with ME treated between January 2008 and December 2011 with a minimal follow up of 6 months. Due to the numerous etiologies and treatment complexity only the 4 major etiologies were analyzed (2159 patients): diabetic macular edema (DME), idiopathic epiretinal membrane (ERM), branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO). CRVO and BRVO were combined (RVO) to obtain larger populations for the statistical analysis. The data were analyzed by presentation with trend lines based on averages containing a minimum of three cases. The visual improvement was considered according to pretreatment vision level.
Results	In idiopathic ERM, 62.5% were treated by vitrectomy with ILM peeling, 10 times more than by anti-VEGF or triamcinolone alone. ME following all RVO was treated by anti-VEGF alone in 33.6% of cases. Combined treatment was chosen in 40% of cases. The single treatment population was large enough to justify a separate analysis. In DME the treatment distribution is more equally divided: 26.6% were treated by anti-VEGF alone, 18.5% were treated by threshold grid laser, in 25.4% combined treatment was chosen. Further treatment groups contained ILM peeling, triamcinolone alone and sub-threshold grid laser.
Conclusion	In all ME etiologies, ILM peeling provides the most visual improvement without resulting in more complications than the other treatments. Second best results are achieved by intravitreal anti-VEGF injection, followed by ILM peeling combined with intravitreal triamcinolone injection.

Authors 1

Last name	PINXTEN
Initials	I
Department	UZ Leuven
City	Leuven

Authors 2

Last name	Van Calster
Initials	J
Department	UZ Leuven
City	Leuven

Authors 3

Last name	Ducournau
Initials	D
Department	Clinique Sourdille
City	Nantes

Authors 4

Last name	Stalmans
Initials	P
Department	UZ Leuven
City	Leuven