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Title

Impact of a switch to preservative free Dorzolamide-Timolol on ocular surface disease symptoms

Purpose	To study the impact of a switch from a preserved to preservative free dorzolamide-timolol fixed combination (Cosopt® unit dose) on ocular surface symptoms self-reported by patients.
Methods	An 8-week multi-centre, prospective, observational study including glaucoma patients who were switched from a preserved glaucoma eye drop drug to unpreserved dorzolamide-timolol. The Glaucoma Symptom Scale items (GSS functional, symptom and total scores; 0 to 100, the higher the better) were completed by patients at baseline, week 4 and 8. Pairwise t-tests were used for changes from baseline in this interim analysis.
Results	77 patients were included (66.5 years; 36% male) and 55 reached week 8 at the time of the interim analysis. GSS total score improved from 65.1 (baseline), to 76.8 (week 4) and 79.9 (week 8; P<0.0001). Respective baseline, week 4 and 8 average scores were 60.0, 74.6 and 78.7 (P<0.0001) for the GSS symptom score and 72.9, 80.3 and 81.6 (P<0.006) for the GSS functional score. All the OSD symptoms had a decrease in prevalence: burning from 72.7% to 50.9%, tearing from 49.4% to 34.6%, dryness feeling from 63.6% to 34.6%, itching from 54.6% to 21.8%, soreness from 50.7% to 41.8% and foreign body sensation from 62.3% to 34.6%. No other adverse events were spontaneously reported.
Conclusion	This observational survey demonstrated that, in daily practice, a switch to preservative free dorzolamide-timolol fixed combination, improves significantly patient self reported symptoms related to ocular surface disease. All GSS scores had improved at week 4 and even more at week 8. A final analysis on the total study patient population will be available and presented at the OB meeting.

Authors 1

Last name	STALMANS
Initials	I
Department	UZ Leuven
City	Leuven

Authors 2

Last name	Berdeaux
Initials	G
Department	IMS HEOR
City	Vilvoorde

Authors 3

Last name	Boons
Initials	S
Department	UZ Leuven
City	Leuven

Authors 4

Last name	Vandewalle
Initials	E
Department	UZ Leuven
City	Leuven