THE BELGIAN OPHTHALMIC ASSOCIATIONS
View abstract
This abstract is assigned to session BOG-SBO 1 Medische retina/ Rétine médicale
| Title | Long-term Outcome of ocular Behcet Disease |
| Abstract Nr. | A1018 |
| Purpose | In the last 2 decades new immunosuppressive drugs have been introduced for treatment of Ocular Adamantiades- Behcet Disease (ABD). Although short term prospective studies have proven benefit of these drugs, few comparative studies or long-term studies have been carried out. |
| Methods | 51 Consenting ABD patients who visited the uveitis clinic in the first 3 months of 2004 with a follow-up > 3 years were included. Follow-up was divided in 1 month periods and the relation treatment vs. disease control and VA was studied. In order to compare current with past prognosis, patients were divided in 3 groups of 17 patients according to date of 1st presentation: group A 1966-88 ; B 1989-95 ; C 1995-2001 |
| Results | Mean follow up was 12 years. A total of 13749 1 month periods were studied. Visual prognosis and disease control at each time (calculated since onset) during follow up was best in group C compared to group B and A (p = 0.00). Treatment was compared with steroid monotherapy. During periods of active disease, combination steroids-Methotrexate (MTX) was best. Steroid-Cyclosporine A (CSA) and Steroid-Chlorambucil were also better than steroids alone. No benefit could be detected using steroids-Mycophenolate Mofetil (MMF) or steroid-azathioprine. In periods of quiescent disease, superior control and visual outcome was achieved with combination of steroids with MTX, CSA or MMF. |
| Conclusion | New therapies for ocular Behcet disease have been introduced over the last decades and have improved prognosis significantly. Surprisingly, in our series the combination of Methotrexate and steroids seemed the most successful bi-therapy. |
Author 1
| Last name | MISSOTTEN |
| Initials | T |
| Department | Moorfields Eye Hospital |
| City | London |
Author 2
| Last name | LAU |
| Initials | C |
| Department | Moorfields Eye Hospital |
| City | London |
Author 3
| Last name | LIGHTMAN |
| Initials | S |
| Department | Moorfields Eye Hospital |
| City | London |