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Title	Intracameral bevacizumab as an adjunct to trabeculectomy: a one year prospective, randomized study.
Abstract Nr.	1045

Purpose	To investigate the efficacy and safety of a single intracameral bevacizumab injection to improve the outcome of trabeculectomy.
Methods	A 12-month, prospective, randomized, double-masked, placebo-controlled trial. Patients with medically uncontrolled open-angle glaucoma scheduled for a primary trabeculectomy were recruited and randomized to receive 50 µl of either bevacizumab (1.25 mg) or placebo (balanced salt solution) peroperatively. Absolute success was defined as intraocular pressure (IOP) ≤ 18 mmHg and > 5 mmHg with at least 30% reduction from baseline and no loss of light perception. Success through the use of additional medical and/or surgical IOP-lowering treatments was defined as qualified success.
Results	138 patients completed a 12-month follow-up, 69 of whom in the bevacizumab treated group. IOP at 1 year postoperatively was significantly lower than baseline (placebo: 25.6±9.9mmHg vs. 11.5±3.9mmHg, p<0.01; bevacizumab: 24.8±8.1mmHg vs. 11.9±3.8mmHg, p<0.01), with no difference between treatment groups (p=0.69). However, absolute success was higher in the bevacizumab group (71% vs. 51%, p=0.02), with the need for IOP-lowering interventions (needlings) being lower in this group (13% vs. 36%, p=0.003). Complication rates were low and comparable between groups.
Conclusion	Peroperative administration of intracameral bevacizumab significantly reduces the need for additional interventions during the follow-up of patients undergoing trabeculectomy.

Authors 1

Last name	VANDEWALLE
Initials	E
Department	UZLeuven
City	Leuven

Authors 2

Last name	Abegao Pinto
Initials	L
Department	Centro Hospitalar Lisboa Central
City	Lisbon

Authors 3

Last name	Van Bergen
Initials	T
Department	KULeuven
City	Leuven

Authors 4

Last name	Moons
Initials	L
Department	KULeuven
City	Leuven

Authors 5

Last name	Spileers
Initials	W
Department	UZLeuven
City	Leuven

Authors 6

Last name	Zeyen
Initials	T
Department	UZLeuven
City	Leuven

Authors 7

Last name	Stalmans
Initials	I
Department	UZLeuven
City	Leuven