Titel | Immunohistochemical characterization of a retinal hamartoma versus common puckers |
Abstract Nr. | 2033 |
Doel | To describe the immunohistochemical features of a retinal hamartoma and compare it with idiopatic common puckers |
Methodes | A 38 y old man was referred for preretinal fibrosis on his right eye. There was loss of vision for more than 8 years with metamorphopsia. The left eye was normal. Oct imaging showed an epiretinal fibrosis with extensive macular oedema. A 27Gauge vitrectomy was performed. The lamina limitans interna (ilm) was peeled after staining with Membrane Blue Dual and sent for histopathology. |
Resultaten | After removal the epiretinal membrane was immediately fixed with PreservCyt® in a ThinPrep® container. The specimen was routinely processed by the Cellient® embedding system. Microscopy showed a folded Pas positive membrane, recognized as ilm with on one side some glial remnants and on the other side a cuboidal non-pigmented epithelium. The glial remnants stained with glial fibrillar protein (gfap), the epithelium with prekeratin AE1/AE3. CD 34 stain was positive in preretinal capillaries. Common puckers showed also material with glial and epithelial caracteristics. |
Conclusie | A strange retinal fibrosis consisted of glial tissue and a row of superficial cuboidal non-pigmented epithelium cells. This kind of hamartoma with immunohistological description was never investigated. |
Naam | VAN GINDERDEUREN |
Initialen | R |
Instituut | Oogziekten en Pathologie |
Stad | Leuven |
Naam | Stalmans |
Initialen | P |
Instituut | Oogziekten |
Stad | Leuven |