Titel | Use of local chemotherapy drops in conjunctival premalignant lesions |
Abstract Nr. | 1058 |
Doel | To investigate the results of chemotherapeutic (adjuvant) therapy in patients with a premalignant conjunctival tumor (melanosis or epithelial dysplasia) |
Methodes | Retrospective study |
Resultaten | In 7 patients with epithelial dysplasia and in 5 patients with conjunctival melanosis Mitomycin C 0.02% or 5-Fluoro-Uracil 1% drops were used. Drops were applied for 2 weeks, and the result was evaluated; in all but one patient a second cycle of 2 weeks (4 times a day) was applied. No recurrence was seen in the patients with epithelial dysplasia; in 2 patients with melanosis further therapy was necessary. Two patients stopped the therapy prematurely because of severe corneal pain. |
Conclusie | MMC and 5-FU are very effective treatments for premalignant conjunctival tumors. The therapies are well-tolerated. In patients with severe corneal pain, topical IFN alpha-2b may be a good alternative. |
Naam | PRUD'HOMME |
Initialen | S |
Instituut | Departement Oftalmologie, KULeuven |
Stad | Leuven |
Naam | SPILEERS |
Initialen | W |
Instituut | Departement Oftalmologie, KULeuven |
Stad | Leuven |
Naam | MISSOTTEN |
Initialen | G |
Instituut | Departement Oftalmologie, KULeuven |
Stad | Leuven |