Titel | A retrospective study on endogenous endophthalmitis in a UK tertiary referral hospital |
Abstract Nr. | 2040 |
Doel | The aim of this study was to investigate the clinical features in endogenous endophthalmitis cases. |
Methodes | We conducted a retrospective chart review of patients treated for endogenous endophthalmitis at Royal Hallamshire Hospital, Sheffield, UK between January 2013 and August 2015. |
Resultaten | Endogenous endophthalmitis was diagnosed in 17 eyes of 14 patients. Patients' ages ranged from 38 to 85 years (mean: 67 years). Visual acuity at presentation was hand movements or better in 9 eyes. Nine patients were initially misdiagnosed, mainly as acute anterior uveitis. Prompt aqueous, vitreous and blood cultures were obtained in 10 patients. Three patients had vitreous sampling performed during vitrectomy and one patient necessitated evisceration. Initial treatment consisted of intravitreal therapeutic substances in 14 eyes and early vitrectomy in 3 eyes. Positive cultures were obtained in 12 patients. Of these, 7 were caused by gram-positive cocci and 5 cases were fungal. Twelve patients had underlying systemic disease and a source of infection was identified in 10 out of 14 patients. Four patients (28,6%) died in the months following diagnosis. At last follow-up, 7 eyes (41,2%) had hand motion vision or better. |
Conclusie | Endogenous endophthalmitis is a rare sight-threatening disease associated with both diagnostic and therapeutic challenges. Our cohort shows an initial misdiagnosis rate of 64% and poor visual outcome. The significant mortality ratio underlines the need for thorough systemic evaluation. |
Naam | KREPS |
Initialen | EO |
Instituut | Dpt of Ophthalmology, Ghent University Hospitals |
Stad | Ghent |
Naam | ROGERS |
Initialen | NK |
Instituut | Dpt of Ophthalmology, Sheffield Teaching Hospitals |
Stad | Sheffield |
Naam | RENNIE |
Initialen | IG |
Instituut | Dpt of Ophthalmology, Sheffield Teaching Hospitals |
Stad | Sheffield |