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Cet abstract a été assigné à session AOB Poster session 1 - Glaucoma – Posterior segment/Retinal disease
TitreIntravitreal injected fluid dispersion: importance of injection technique.
Abstract Nr.1025
ButTo evaluate the dispersion of intravitreal injected solutions and to investigate the influence of varying injection techniques.
MéthodesProspective experimental study using enucleated porcine eyes and ultra-high resolution computed tomography (UHRCT) scanning to visualize iomeprol intravitreal dispersion. 60 porcine eyes were divided over 12 different groups according to the injection procedure: fast (2 sec) or slow (10 sec) injection speed and needle tip location (6 and 12 mm needle shaft insertion or premacular needle tip placement verified by indirect ophthalmoscopy). For each of these combinations eyes were either injected the combination of V20I (which is an analogue of ocriplasmin) and iomeprol or iomeprol alone. Distance to the macula and volume measurements were performed at 1, 2, 3 and 5 hours after injection.
RésultatsSixty fresh enucleated porcine eyes were injected with iomeprol or a combination of iomeprol and V20I. The measured contrast bolus volume increases slowly over time to an average of 0.70 (p=0.03), 1.04 (P=0.006) and 0.79 (p=0.0001) cm³ 5 hours after the injection for 6, 12mm and premacular intravitreal injections, respectively. The distance to the macular marker was significantly lower for premacular injections in respect to 6 mm needle shaft insertion depths.
ConclusionUHRCT with 3-D reconstruction offers the possibility to study the dispersion of intravitreal injected solutions in a non-invasive manner. Premacular intravitreal injections under indirect funduscopic guidance assured a targeted contrast delivery.
Conflit d'intérêtOui
Détails conflits d'intérêtPeter Stalmans receives lecture fees from Alcon, DORC, Haag-Streit and Thrombogenics; is a consultant for Alcon, Bausch&Lomb, DORC, Nano-Retina, Zeiss and Vitreq; and receives grant support from Thrombogenics.
Auteur 1
NomWILLEKENS
InitialesK
InstitutUZ Leuven
VilleLeuven
Auteur 2
NomReyns
InitialesG
InstitutThromboGenics NV
VilleLeuven
Auteur 3
NomDiricx
InitialesM
InstitutThromboGenics NV
VilleLeuven
Auteur 4
NomVanhove
InitialesM
InstitutThromboGenics NV
VilleLeuven
Auteur 5
NomNoppen
InitialesB
InstitutThromboGenics NV
VilleLeuven
Auteur 6
NomCoudyzer
InitialesW
InstitutUZ Leuven
VilleLeuven
Auteur 7
NomNi
InitialesY
InstitutUZ Leuven
VilleLeuven
Auteur 8
NomFeyen
InitialesJHM
InstitutThromboGenics NV
VilleLeuven
Auteur 9
NomStalmans
InitialesP
InstitutUZ Leuven
VilleLeuven
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