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Deze abstract is toegekend aan sessie AOB Poster session 1 - Glaucoma – Posterior segment/Retinal disease
TitelBlepharoptosis and external ophthalmoplegia associated with long-term antiretroviral therapy in human immunodeficiency virus-infected patients
Abstract Nr.1031
DoelTo present two cases of patients infected with human immunodeficiency virus (HIV) who developed a clinical picture of chronic progressive external ophthalmoplegia (CPEO) after long-term antiretroviral therapy.
MethodesIn these 2 adult patients presenting with a clinical picture of CPEO, a biological and radiological work-up was performed to disclose myasthenia or classic CPEO of mitonchondrial origin. These patients share in common more than 10 years of antiretroviral therapy for HIV.
ResultatenThe biological and radiological work up could not elicit myasthenia nor classic CPEO as the cause of our patient’s clinical picture. Acetylcholine receptor antibody and lactate titers were not increased. Orbital MRI was rather unremarkable.
ConclusieWe conclude that our patients have a CPEO-like syndrome relied to HIV disease and antiretroviral therapy, as already described in the literature. Antiretroviral therapy includes nucleoside reverse-transcriptase inhibitors and protease inhibitors, both of which are known causes of skeletal myopathy. Nucleoside reverse-transcriptase inhibitors interfers with mitochondrial DNA polymerase gamma. Mutations in the same enzyme have been demonstrated in patients with CPEO. Mitochondrial dysfunction might be the common link between these 2 similar pictures of different origins.
BelangenverstrengelingNee
Auteur 1
NaamBOUAICH
InitialenK
InstituutHôpital universitaire Erasme
StadBruxelles
Auteur 2
NaamRemiche
InitialenG
InstituutHôpital universitaire Erasme
StadBruxelles
Auteur 3
NaamGoffard
InitialenJC
InstituutHôpital universitaire Erasme
StadBruxelles
Auteur 4
NaamDavid
InitialenP
InstituutHôpital universitaire Erasme
StadBruxelles
Auteur 5
NaamVan Nechel
InitialenC
InstituutHôpital universitaire Erasme
StadBruxelles
Auteur 6
NaamCordonnier
InitialenM
InstituutHôpital universitaire Erasme
StadBruxelles
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