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Title	Quantification of changes in foveal capillary architecture induced by idiopathic epiretinal membrane using OCT-Angiography
Abstract Nr.	2073

Purpose	To quantify the extent and depth of distortion of the foveal capillary architecture due to traction of idiopathic epiretinal membrane (ERM) using optical coherence tomography angiography (OCT-A).
Methods	Multimodal imaging including OCT-A (Angiovue, Optovue) was performed in 42 eyes with idiopathic ERM (72.4 years +/-6.8). Based on 6x6mm2 OCT-A images, a macular vessel density ratio (MVR=VDfo [Vessel density foveal region]/VDp [vessel density parafoveal region]) was calculated for the superficial (s), deep (d) and full-thickness (f) slabs to assess a depth-resolved, non-invasive evaluation of foveal distortion. The acquired data were subdivided in a patient group with mild and severe BCVA reduction due to ERM. Data was compared to age-matched healthy controls.
Results	In all three slabs, MVR was significantly smaller in the control group in comparison with the ERM group: MVRs: 0.63 +/- 0,1 vs 0.83 +/- 0.1 (p>0.001); MVRd: 0.60 +/- 0.1 vs 0.73 +/- 0.1 (p<0.001); MVRf: 0.68 +/- 0.1 vs 0.82 +/- 0.1 (p<0.001). Group 1 (BCVA <0.4 LogMar) showed a significantly higher MVR in comparison with the control group in the superf. plexus only: MVRs: 0.64 +/- 0.1 vs 0.78 +/- 0.1 (p<0.001); MVRd: 0.60 +/- 0.1 vs 0.65 +/- 0.2 (p=0.3); MVRf: 0.68 +/- 0.1 vs 0.77 +/- 0.1 (p=0.01). However, group 2 (BCVA >= 0.4 LogMar) showed a significantly higher MVR in all three slabs: MVRs: 0.64 +/- 0.1 vs 0.86 +/- 0.1 (p<0.001); MVRd: 0.60 +/- 0.1 vs 0.77 +/- 0.2 (p<0.001); MVRf: 0.68 +/- 0.1 vs 0.85 +/- 0.1 (p<0.001).
Conclusion	Assessing MVR using OCT-A may serve as a tool to quantify the extent and depth of distortion of the foveal capillary architecture due to traction of ERM.
Conflict of interest	No

Authors 1

Last name	NELIS
Initials	P
Department	UKM, UZB
City	Muenster, Brussels

Authors 2

Last name	Alten
Initials	F
Department	UKM
City	Muenster

Authors 3

Last name	Clemens
Initials	C
Department	UKM
City	Muenster

Authors 4

Last name	Heiduschka
Initials	P
Department	UKM
City	Muenster

Authors 5

Last name	Van Lint
Initials	M
Department	UZB
City	Brussels

Authors 6

Last name	Ten Tusscher
Initials	M
Department	UZB
City	Brussels

Authors 7

Last name	Eter
Initials	N
Department	UKM
City	Muenster