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Title	Infantile orbital hemangioma treated with propranolol: 2 cases
Abstract Nr.	3035

Purpose	We report two cases of infantile orbital hemangioma with proptosis, successfully treated with propranolol.
Methods	Observational report of two cases with infantile orbital hemangioma treated with propranolol, including close pediatric and ophthalmological follow-up and imaging.
Results	A six week-old girl with a history of premature birth, presented at the pediatric clinic with progressive, unilateral exophthalmos. Ophthalmological evaluation showed normal pupillary reflexes and IOP, with proptosis of the right eye, more pronounced during Valsalva-maneuver. MRI was suggestive for capillary hemangioma. Propranolol was promptly started after cardiological check-up, with a spectacular response seen by day one of treatment. A 5 month-old boy, born as triplet at 34 weeks postmenstrual age, showed a unilateral proptosis of the right eye, increasing with crying. Furthermore, there were no ophthalmological abnormalities. MRI imaging showed a massive capillary hemangioma in the right orbit. After two weeks of treatment with oral propranolol, the exophthalmos and hemangioma were completely disappeared.
Conclusion	Propranolol seems to be a rapidly effective and safe treatment for infantile orbital hemangioma. Nevertheless, administering systemic medication to an infant with a benign condition requires careful multidisciplinary consideration and experienced follow-up, considering the risk of side effects, relapse and resistance to propranolol.
Conflict of interest	No

Authors 1

Last name	DEKLERCK
Initials	EJ
Department	Dpt of Ophthalmology, Ghent University Hospital/AZ Sint-Jan Hospital
City	Ghent/Bruges

Authors 2

Last name	VULSTEKE
Initials	C
Department	Dpt of Ophthalmology, AZ Delta Hospital
City	Roeselare

Authors 3

Last name	MATTHIJS
Initials	I
Department	Dpt of Pediatrics, AZ Delta Hospital
City	Roeselare

Authors 4

Last name	DELBEKE
Initials	P
Department	Dpt of Ophthalmology, Ghent University Hospital/AZ Sint-Jan Hospital
City	Ghent/Bruges