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This abstract is assigned to session AOB and FRO E-Posters

Title	Punctate inner choroidopathy in monozygotic twins
Abstract Nr.	3039

Purpose	To report punctate inner choroidopathy (PIC) in monozygotic twins
Methods	Observation of Caucasian monozygotic twin sisters, who presented 2 years apart with PIC
Results	At presentation, the first sister manifested unilateral multiple small yellow-white chorioretinal lesions in the posterior pole, without cellular activity. One month later, the lesions had become bilateral. After initial diagnosis of serpiginous choroiditis she was treated with intravitreal anti-VEGF and steroids, to no effect. Systemic treatment was initiated with tuberculostatics, steroids and cyclosporin with limited therapeutic effect. Ledertrexate was added but in the meantime she developed a subretinal neovascular membrane, refractory to anti-VEGF. After consulting our department an ophthalmological and general work up confirmed the diagnosis of PIC. Tuberculostatics and cyclosporin were stopped and steroids tapered off. Adalimumab was initiated successfully. The twin presented 2 years later with a unilateral neovascular membrane, initially diagnosed as a Fuchs spot. Autofluorescence imaging revealed bilateral small white dots in the retinal midperiphery, without signs of active inflammation, confirming PIC.
Conclusion	PIC is a recurrent, bilateral, chorioretinal inflammatory disease, usually in young, myopic women. To our knowledge this is the first report of PIC in monozygotic twins. Although the pathogenesis of PIC is still unclear, these cases suggest a possible genetic association
Conflict of interest	No

Authors 1

Last name	PEETERS
Initials	D
Department	Faculty of Medicine, Ghent University

Authors 2

Last name	SYS
Initials	C
Department	Department of Ophthalmology, Ghent University Hospital

Authors 3

Last name	DE ZAEYTIJD
Initials	J
Department	Department of Ophthalmology, Ghent University Hospital

Authors 4

Last name	LEROY
Initials	BP
Department	Department of Ophthalmology, Center for Medical Genetics, Ghent University Hospital & University

Authors 5

Last name	DE SCHRYVER
Initials	I
Department	Department of Ophthalmology, Ghent University Hospital