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This abstract is assigned to session AOB and FRO E-Posters

Title	Regrowth of the Endothelium after Descemetorhexis: two case reports
Abstract Nr.	3002

Purpose	To present two cases of Fuchs endothelial dystrophy with corneal endothelial regrowth after Descemetorhexis.
Methods	Two patients with Fuchs endothelial dystrophy underwent a different treatment approach. The first patient received Descemet membrane endothelial keratoplasty (DMEK) after Descemetorhexis. 4 months after the initial procedure, graft detachment was detected requiring graft removal. The second patient received Descemet stripping during cataract surgery. However, subsequent keratoplasty could not take place due to lack of donors.
Results	Patient 1: 1 week after surgery, Optical Coherence tomography showed central graft dehiscence but decreased corneal oedema and improved vision from 20/50 to 20/25. Newly developing central corneal endothelial cells were verified by confocal and specular microscopy. Further endothelial spreading was seen after graft removal. 18 months after the initial surgery, vision improved to 20/20. Patient 2: 6 weeks after surgery, spontaneous corneal endothelial cell migration was seen. A clear and stable cornea was formed at 4 months and subsequently the vision acuity improved from 20/40 to 20/20.
Conclusion	These two cases provide evidence of spontaneous endothelial regrowth after Descemetorhexis, making it a potential treatment for endothelial dystrophy. An extra advantage is that no donor material is needed, so it could also be used in countries without eye banking infrastructure.
Conflict of interest	No

Authors 1

Last name	DELWICHE
Initials	N
Department	Universiteit Antwerpen
City	Antwerpen

Authors 2

Last name	Tassignon
Initials	MJ
Department	Universitair Ziekenhuis Antwerpen (UZA)
City	Edegem

Authors 3

Last name	Ní Dhubhghaill
Initials	S
Department	Universitair Ziekenhuis Antwerpen (UZA)
City	Edegem