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Title	Comparing anterior segment optical coherence tomography and ultrasound biomicroscopy with histopathology in measurement of corneal and bulbar conjunctival tumors depth
Abstract Nr.	2083

Purpose	To compare tumor depth measured by histopathology(HP) with measurements by Ultrasound Biomicroscopy (UBM) and Anterior Segment Optical Coherence Tomography (A-OCT),to investigate whether these techniques are as accurate as HP.
Methods	35 patients with 42 corneal or conjunctival bulbar tumors were imaged with A-OCT and UBM in order to measure tumor depth.11 of the tumors were excised and analyzed on histopathology. The correlation of the depth measurement on HP versus A-OCT and UBM was statistically analyzed.When the tumor was not excised, depth measurements on A-OCT versus UBM were compared.
Results	Statistical analysis showed that UBM and HP measurements of tumor depth are positively correlated,as are UBM and A-OCT measurements.It was not possible to obtain statistically significant data for the correlation between HP and A-OCT measurements because of the small study population.Image quality was overall beter with A-OCT than with UBM,but in 12 tumors,tumor depth measurement on A-OCT was impossible because of posterior tumor back shadowing.
Conclusion	UBM can measure tumor depth as accurately as HP.Tumor depth measurements on A-OCT and UBM are positively correlated.No relation was found between HP and A-OCT measurements because of the small study population.A larger study is needed to investigate whether measurement of tumor depth with A-OCT is as accurate as HP.Because of the drawbacks of conjunctival tumor depth measurements on histopathology,we think that it is possible that A-OCT and UBM could become the golden standard for measuring corneal and bulbar conjunctival tumor depth.We would use A-OCT if the tumor is not too thick or pigmented and UBM in case of posterior tumor back shadowing.
Conflict of interest	No

Authors 1

Last name	LAUWERS
Initials	N
Department	UZA
City	Edegem

Authors 2

Last name	MERTENS
Initials	M
Department	UZA
City	Edegem

Authors 3

Last name	JANSSENS
Initials	K
Department	UZA
City	Edegem

Authors 4

Last name	MATHYSEN
Initials	D
Department	UZA
City	Edegem

Authors 5

Last name	DE KEIZER
Initials	RJW
Department	UZA
City	Edegem

Authors 6

Last name	DE GROOT
Initials	V
Department	UZA
City	Edegem