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Type de présentation	Oral presentation
Titre	Morphological characterization and clinical effects of stromal alterations after intracorneal ring segments (ICRS) implantation in keratoconus

But	To analyze the stromal tissue changes after ICRS implantation and their refractive and topographic effects in patients with keratoconus.
Méthodes	This retrospective case series included 15 patients with clinical peri-segmental lamellar channel deposits after ICRS implantation for keratoconus. The stromal changes were investigated using in-vivo confocal microscopy. Two patients underwent a penetrating keratoplasty after ICRS implantation, the explanted corneas were processed for histopathology and transmission electron microscopy (TEM). Refractive and topographic effects were investigated comparing the uncorrected (UDVA) and corrected (CDVA) distance visual acuity, spherical equivalent (SE), flat (K1), steep (K2) and steepest (Kmax) keratometry before and after detection of lamellar channel deposits.
Résultats	In-vivo confocal microscopy revealed diffuse linear and focal granular hyperreflective structures. Histologically, there was mild proliferation of fibroblasts and fibrosis. TEM demonstrated focal accumulations of degenerated keratocytes with cytoplasmic lipid inclusions. There were no significant changes for UDVA (Δ = 0.0 ± 0.2 logMAR; p = 0.67), CDVA (Δ = 0.0 ± 0.1 logMAR; p = 0.32), SE (Δ 0.1 ± 0.9 D; p = 0.22), K1 (Δ = 0.3 ± 1.0 D; p = 0.28), K2 (Δ = 0.1 ± 0.9 D; p = 0.51) and Kmax (Δ = 0.3 ± 1.5 D; p = 0.17).
Conclusion	Two types of structural stromal changes were identified: (1) diffuse peri-segmental fibrosis and (2) lamellar channel deposits. These structural changes showed no evidence of refractive or topographic effect.
Conflit d'intérêt	Non

Auteur 1

Nom	HAMON
Initiales	L
Institut	Universitätsklinikum des Saarlandes
Ville	Homburg

Auteur 2

Nom	Schlötzer-Schrehardt
Initiales	U
Institut	Universitätsklinikum Erlangen
Ville	Erlangen

Auteur 3

Nom	Flockerzi
Initiales	FA
Institut	Universitätsklinikum des Saarlandes
Ville	Homburg

Auteur 4

Nom	Seitz
Initiales	B
Institut	Universitätsklinikum des Saarlandes
Ville	Homburg

Auteur 5

Nom	Daas
Initiales	L
Institut	Universitätsklinikum des Saarlandes
Ville	Homburg