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TitelPlasma omega 3 fatty acids and risk for age-related maculopathy: the Alienor Study
DoelTo assess the associations of age-related maculopathy (ARM) with plasma concentrations of omega 3 polyunsaturated fatty acids (PUFA).
MethodesSubjects were recruited from the ongoing 3C cohort, bearing on the vascular risk factors for dementia. They were initially included in 1999-2001 and followed-up every two years. In 2006-2008, 963 subjects, aged 73 years or more, had an eye examination. ARM was graded from non mydriatic colour retinal photographs into 4 stages, according to the international classification: early ARM 1, early ARM 2, late atrophic ARM and late neovascular ARM. Plasma fatty acids were measured by gas chromatography, from fasting blood samples drawn at baseline of the 3 City Study (1999-2001).
ResultatenAfter multivariate adjustment, higher plasma total and long-chain omega 3 PUFA were associated with reduced risk for late atrophic ARM (OR=0.50 for 1-standard deviation increase, 95 % confidence interval (CI) : 0.27-0.93 and OR=0.52, 95 % CI: 0.28-0.97, respectively), but not with other stages. Among specific omega 3 PUFA, only eicosapentaenoic acid (EPA) was significantly associated with reduced risk for late atrophic ARM (OR=0.33, 95 % CI: 0.15-0.89). Other types of fatty acids (saturated, monounsaturated, polyunsaturated) were not significantly associated with the risk for ARM.
ConclusieThis study shows an inverse association of ARM with plasma omega 3 PUFA, consistently with previous observations concerning dietary intakes. Omega 3 PUFA may prove useful for the prevention of ARM, in particular in its atrophic form, for which no treatment is available.
Auteur 1
NaamROUGIER
InitialenMB
InstituutCHU
StadBordeaux, France
Auteur 2
NaamMERLE
InitialenB
InstituutInserm, U897
StadBordeaux
Auteur 3
NaamKOROBELNIK
InitialenJF
InstituutCHU
StadBordeaux
Auteur 4
NaamDELYFER
InitialenMN
InstituutCHU
StadBordeaux
Auteur 5
NaamLE GOFF
InitialenM
InstituutInserm, U897
StadBordeaux
Auteur 6
NaamDELCOURT
InitialenC
InstituutInserm, U897
StadBordeaux
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