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TitelOrbital Inflammation after use the of Zoledronic Acid for metastasized prostate carcinoma.
DoelTo descibe a case of orbital inflammation and unilateral exophthalmia after the use of zoledronic acid for metastasized prostate carcinoma.
MethodesCase description and literature review
ResultatenA 71-year old male was referred to the ophthalmology department with swelling of upper and lower eyelids and conjunctiva, redness of the right eye and pain. There were no complaints of the left eye. Visual acuity was 0.8 on both sides. There was no anterior uveitis. Fundus examination results were normal OU. Exophthalmometry measured 3 mm proptosis of the right eye. Computed Tomography (CT) showed proptosis, fat stranding, but no identifiable mass in the right orbit (figure 1). Ultrasound did not show signs of scleritis OD. Blood screening showed no abnormalities, except a decreased Thyroid Stimulating Hormone (TSH). The inflammation of the right orbital tissue was diagnosed at the end of treatment with intravenous zoledronic acid for metastasized prostate carcinoma (with bone metastases). As such, a bisphosphonate-triggered orbital inflammation was diagnosed, the bisphosphonates were discontinued and oral prednisone 32 mg was started for 3 weeks. Within five days the symptoms disappeared, and did not return (follow-up 7 months).
ConclusieIn conclusion, in patients receiving bisphosphonates close attention should be given to ocular signs or symptoms
Auteur 1
NaamMISSOTTEN
InitialenGS
InstituutVirga Jesse Ziekenhuis
StadHasselt
Auteur 2
NaamVerheezen
InitialenY
InstituutVirga Jesse Ziekenhuis - Oncologie
StadHasselt
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