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Title	Risk factors for growth of choroidal nevi with a juxtapapillary location in 90 consecutive patients
Abstract Nr.	3008

Purpose	To define the real incidence of tumor growth of juxtapapillary choroidal nevi and the clinical and ultrasonographic risk factors predictive of their growth.
Methods	This retrospective case series included 90 juxtapapillary nevi (located at < 500 µm to disc) with no other risk factor for growth such as orange pigment, subretinal fluid, thickness greater than 2mm or tumor-related visual symptoms (known as TFSOM) at initial visit. The patients were followed since December 1997 till July 2017 with a mean follow-up of 83 months (range: 6-215).
Results	The mean age at diagnosis was 62 years. The mean largest tumor diameter was 3.5mm (range: 0.5-10) and tumor thickness 1.6mm (range: 1-2). Lesion growth was observed in 2 of the 90 nevi (2%) after 81 months for the first one, treated subsequently with transpupillary thermotherapy (TTT), and after 82 months for the second one, treated subsequently with TTT and Iodine-125 plaque. No patient developed metastatic disease. Due to the small number of events, statistical analyses did not allow us to find predictive factors for tumor growth in our series.
Conclusion	Among posterior uveal melanocytic lesions with a juxtapapillary location and no other factor predictive of growth such as orange pigment, subretinal fluid, thickness greater than 2mm or tumor-related visual symptoms, the incidence of tumor growth was reported to be 2% in our series. The juxtapapillary location appeared to carry a lower risk for malignant transformation than the other known risk factors.
Conflict of interest	No

Authors 1

Last name	RAMARD
Initials	H
Department	Cliniques Universitaires St Luc
City	Brussels

Authors 2

Last name	Bartoszek
Initials	P
Department	Cliniques Universitaires St Luc
City	Brussels

Authors 3

Last name	De Potter
Initials	P
Department	Cliniques Universitaires St Luc
City	Brussels