THE BELGIAN OPHTHALMIC ASSOCIATIONS
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This abstract is assigned to session SBO-BOG Free papers: Miscellaneous
| Title | Plaque Radiotherapy and adjuvant delimiting transpupillary thermotherapy for choroidal melanoma |
| Abstract Nr. | 150 |
| Purpose | To evaluate tumor control and treatment complications following Iodine 125 plaque radiotherapy (IPR) combined with delimiting transpupillary thermotherapy (DTTT) for newly diagnosed choroidal melanoma. |
| Methods | Design : Prospective randomized case series Participants : Of the 221 patients treated with a median radiotherapy dose to tumor apex of 90 Gy, 91 patients (41%) were managed with IPR alone (control group) and 130 (59%) received adjuvant DTTT (treatment group). Methods : For those patients randomized to DTTT, one session of TTT was provided at the time of plaque removal in 99 cases (76%) and 31 cases (24%) after complete resorption of the subretinal fluid (mean interval of 11 months). |
| Results | After a mean follow-up of 54 months, tumor recurrence was documented in 5 patients (5%) in the control group, and in 3 (2%) in the DTTT group. Treatment-induced complications included retinopathy in 55%, papillopathy in 16%, vitreous hemorrhage in 29%, neovascular glaucoma (NVG) in 17% and late enucleation in 9% in the control group. In the DTTT group, retinopathy was documented in 66%, papillopathy in 25%, vitreous hemorrhage in 18%, NVG in 7% and late enucleation in 4%. The incidence of vitreous hemorrhage, NVG, and late enucleation was statistically higher in the control group. The higher rate of tumor recurrence in the control group was not statistically significant. |
| Conclusion | Combined DTTT and plaque radiotherapy provides excellent local tumor control and a statistically lower risk for vitreous hemorrhage, NVG, and secondary enucleation. |
Author 1
| Last name | STINGLHAMBER |
| Initials | A |
| Department | Cliniques Universitaires Saint Luc |
| City | Brussels |
Author 2
| Last name | DE POTTER |
| Initials | P |
| Department | Cliniques Universitaires Saint Luc |
| City | Brussels |
Author 3
| Last name | RENARD |
| Initials | L |
| Department | Cliniques Universitaires Saint Luc |
| City | Brussels |