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This abstract is assigned to session SBO-BOG Free papers: Chirurgie retina en vitreum/chirurgie rétine et vitré

Title	Enzymatic vitreolysis with µplasmin: a new tool in the vitreoretinal surgery?
Abstract Nr.	131

Purpose	Several vitreoretinal diseases are caused or enhanced by traction of the posterior vitreous membrane on the macular area, such as: vitreomacular traction syndrome, idiopathic macular hole formation, diabetic retinopathy and even age related macular degeneration. At present, several clinical studies are being performed to evaluate the safety and efficacy of microplasmin to induce a posterior vitreous detachment, avoiding the need to perform a vitrectomy in these patients.
Methods	Patients are randomized to different doses of microplasmin intravitreal injection or a placebo injection (not administered intravitreally). Vitreomacular traction is evaluated at baseline and at several timepoints after administration of the study drug by a masked observer using slit lamp examination, ophthalmoscopy, optical coherence tomography (OCT) and B-scan ultrasound.
Results	At present, injection of microplasmin intravitreally is well tolerated, and is capable of inducing a posterior vitreous detachment in several included patients.
Conclusion	Although clinical studies are far from completed, it seems that microplasmin may become a valuable tool for the vitreoretinal specialist in the treatment of several eye diseases related to vitreomacular traction.

Author 1

Last name	STALMANS
Initials	P
Department	Dept. Ophthalmology UZLeuven
City	Leuven

Author 2

Last name	VAN CALSTER
Initials	J
Department	Dept. Ophthalmology UZLeuven
City	Leuven

Author 3

Last name	VAN AKEN
Initials	E
Department	UZGent
City	Gent

Author 4

Last name	DELAEY
Initials	C
Department	UZGent
City	Gent

Author 5

Last name	DE SMET
Initials	MD
Department	Middelheim Hospital
City	Antwerp