THE BELGIAN OPHTHALMIC ASSOCIATIONS
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This abstract is assigned to session Poster Rapid Fire session
| Title | Colour vision deficiency in Stargardt disease |
| Abstract Nr. | P12 |
| Purpose | To investigate whether the colour vision deficiency (CVD) in patients with Stargardt disease (STD) is predominantly in the red-green axis (R/G) as is always described. If present, whether the R/G defect is of the Verriest type 1. And to establish whether there is a correlation between best-corrected visual acuity (BCVA) loss and degree of CVD. |
| Methods | A retrospective, cross-sectional study of 30 patients (60 eyes) with STD who underwent extensive colour vision (CV) testing using Ishihara, Tritan Plate & AO-HRR pseudo-isochromatic (PIC) plates, Panel D-15 & Desaturated Panel D-15 tests under standardised CIE-light conditions. In addition, 9 patients underwent anomaloscopy. All patients had a clinical diagnosis of STD, which was confirmed by the presence of mutations in ABCA4. |
| Results | CV was normal in 10/60 eyes (16,7%) with BCVA between 0.8-1.0. In 50 eyes with BCVA below 0.8 (<0.05 - 0.8), R/G defects were more prominent with decreasing BCVA. Eyes with BCVA <0.1 showed severe R/G defects with additional blue-yellow CVD, pending towards scotopisation. Overall, in these 50 eyes, PIC plates & PD-15 tests showed R/G CVD without predominance of either Verriest type 1 or type II. Anomaloscopy in 9 patients revealed pseudoprotanomaly in 8 and pseudodeuteranomaly in 1. |
| Conclusion | CV is normal in patients with STD and good BCVA. In those with BCVA below 0.8, CVDs are initially and predominantly of the R/G type, with additional B/Y defects manifesting as BCVA declines, eventually leading to scotopisation. A predominance of Verriest type 1 R/G CVD is evident only on anomaloscopy. |
Author 1
| Last name | UVIJLS |
| Initials | A |
| Department | Dept Ophth, Ghent Univ Hosp |
| City | Ghent |
Author 2
| Last name | BREUSEGEM |
| Initials | CM |
| Department | Dept Ophth, Ghent Univ Hosp |
| City | Ghent |
Author 3
| Last name | KESTELYN |
| Initials | P |
| Department | Dept Ophth, Ghent Univ Hosp |
| City | Ghent |
Author 4
| Last name | DE LAEY |
| Initials | JJ |
| Department | Dept Ophth, Ghent Univ Hosp |
| City | Ghent |
Author 5
| Last name | DE BAERE |
| Initials | E |
| Department | Dept Ophth, Ghent Univ Hosp / Ctr Med Genet, Ghent Univ Hosp |
| City | Ghent |
Author 6
| Last name | LEROY |
| Initials | BP |
| Department | Dept Ophth, Ghent Univ Hosp / Ctr Med Genet, Ghent Univ Hosp |
| City | Ghent |