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This abstract is assigned to session BOG-SBO: Medisch netvlies/ Rétine médicale

Title	Risk Factors for Growth of Posterior Uveal Melanocytic Lesions with Thickness Greater than 2 mm
Abstract Nr.	249

Purpose	To better define the clinical risk factors predictive of growth of small melanocytic posterior uveal tumors measuring 2 mm or more in thickness.
Methods	Non comparative observational cases series including 90 patients with suspicious choroidal or cilio-choroidal tumors measuring 2 mm or more in thickness and without other known clinical factors predicting of growth such as orange pigment, subretinal fluid, tumor margin touching disc, or tumor-related visual symptoms at initial visit. Those 90 patients were followed since October 1997 to document growth prior to treatment.
Results	82 lesions (92%) were choroidal and 7 (8%) were cilio-choroidal. The mean age at diagnosis was 63 years (range, 24 to 87). The mean maximum tumor diameter was 9 mm (range, 5 to 16 mm) and tumor thickness 2,6 mm (range, 2 to 4,5 mm). The mean distance to the disc was 5,6 mm (range, 0,5 to 15 mm) and to the fovea 5,4 mm (range, 0 to 15 mm). Of the 90 small melanocytic lesions, 12 (13%) demonstrated growth after a mean follow-up of 40 months (range, 6 to 100 months). No patient developed systemic metastasis. The clinical factors predictive of growth (multivariate analysis-Cox regression) included greater tumor diameter (> 9 mm) and shorter distance to the disc (< 5 mm). The cumulative risks for tumor growth (Kaplan-Meier) were 5% at one year, 15% at 3 years, and 17% at 5 years.
Conclusion	Tumor diameter greater than 9 mm and tumor margin less than 5 mm to disc are two clinical factors to take into consideration when counseling patients with small posterior uveal melanocytic lesions measuring 2 mm or more in thickness at initial presentation.

Author 1

Last name	DE POTTER
Initials	P
Department	Ocular Oncology Unit, Cliniques Universitaires St-Luc
City	Bruxelles

Author 2

Last name	JAMART
Initials	J
Department	Centre de Biostatistique et de Documentation médicale, Cliniques Universitaires de Mont-Godinne
City	Yvoir