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Title	Use of Mitomycin C (MMC) in the treatment of primary acquired melanosis of the conjunctiva
Abstract Nr.	P08

Purpose	Follow-up of topical mitomycin C treatment of primary acquired melanosis (PAM) with atypia.
Methods	Local management, complications and follow-up of 10 patients, treated with MMC 0.02% or 0.04% for PAM with atypia were evaluated. MMC was applicated for four weeks, four times daily.
Results	After two cycli of MMC, melanosis disappeared in all patients. In four patients a progression to melanoma occured within the follow-up time of 54 months, which ended in an exenteration in one case. All patients developed keratoconjunctivitis during treatment, disappearing within 2 weeks after treatment. In one patient a slight sympblepharon developed after 2 cycli of MMC.
Conclusion	Mitomycin C has a value in the management of diffuse and long-standing melanosis with atypia, but can not prevent recurrences, nor the progression to melanoma. The treatment is well-tolerated with our treatment protocol.

Author 1

Last name	MISSOTTEN
Initials	GS
Department	Leids Universitair Medisch Centrum
City	Leiden (NL)

Author 2

Last name	De Wolff-Rouendaal
Initials	D
Department	Leids Universitair Medisch Centrum
City	Leiden (NL)

Author 3

Last name	De Keizer
Initials	RJ
Department	Universiteit Antwerpen
City	Antwerpen