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Deze abstract is toegekend aan sessie SBO-BOG Free papers: Chirurgie retina en vitreum/chirurgie rétine et vitré
TitelEnzymatic vitreolysis with µplasmin: a new tool in the vitreoretinal surgery?
Abstract Nr.131
DoelSeveral vitreoretinal diseases are caused or enhanced by traction of the posterior vitreous membrane on the macular area, such as: vitreomacular traction syndrome, idiopathic macular hole formation, diabetic retinopathy and even age related macular degeneration.
At present, several clinical studies are being performed to evaluate the safety and efficacy of microplasmin to induce a posterior vitreous detachment, avoiding the need to perform a vitrectomy in these patients.
MethodesPatients are randomized to different doses of microplasmin intravitreal injection or a placebo injection (not administered intravitreally).
Vitreomacular traction is evaluated at baseline and at several timepoints after administration of the study drug by a masked observer using slit lamp examination, ophthalmoscopy, optical coherence tomography (OCT) and B-scan ultrasound.
ResultatenAt present, injection of microplasmin intravitreally is well tolerated, and is capable of inducing a posterior vitreous detachment in several included patients.
ConclusieAlthough clinical studies are far from completed, it seems that microplasmin may become a valuable tool for the vitreoretinal specialist in the treatment of several eye diseases related to vitreomacular traction.
Auteur 1
NaamSTALMANS
InitialenP
InstituutDept. Ophthalmology UZLeuven
StadLeuven
Auteur 2
NaamVAN CALSTER
InitialenJ
InstituutDept. Ophthalmology UZLeuven
StadLeuven
Auteur 3
NaamVAN AKEN
InitialenE
InstituutUZGent
StadGent
Auteur 4
NaamDELAEY
InitialenC
InstituutUZGent
StadGent
Auteur 5
NaamDE SMET
InitialenMD
InstituutMiddelheim Hospital
StadAntwerp
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