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Deze abstract is toegekend aan sessie SBO-BOG Free papers: Miscellaneous
TitelTreatment of conjunctival melanoma
Abstract Nr.149
DoelTo describe the diagnosis, treatment and outcome of 200 conjunctival melanomas treated between 1950 and 2005 retrospectively.
MethodesRetrospective descriptive study.
ResultatenThe origin of the conjunctival melanoma was nevus (12), primary acquired melanosis (PAM) (113), de novo (52), or not known (23). Out of 200 patients, 114 had a local recurrence, during the median follow-up of 7.1 years (range 1.5-50.5 years). Non-epibulbar localisation was the most important risk factor for local recurrence and survival. Significantly fewer local recurrences occurred with tumors initially treated with excision and adjuvant brachytherapy ( Sr 90 ), in comparison with tumors treated with excision only or with excision with cryotherapy. Mean tumor thickness was 2.1 mm (standard deviation 1.9 mm). Tumor thickness was also a prognostic factor for survival.
Forty three patients had regional lymph node metastases, mostly to the preauricular lymph nodes. Fifty patients had a distant metastases mainly to the liver and lung.
Tumor-related survival was 86.5% at 5 years, 72% at 10 years and 67% at 15 years.
ConclusiePoor survival was associated with a non-epibulbar melanoma and thicker tumors. In this study, fewer local recurrences were seen when excision was combined by brachytherapy.
Auteur 1
NaamMISSOTTEN
InitialenGS
InstituutLeiden University Medical Center
StadLeiden
Auteur 2
Naamde Wolff-Rouendaal
InitialenD
InstituutLeiden University Medical Center
StadLeiden
Auteur 3
NaamTassignon
InitialenMJ
InstituutUniversitair Ziekenhuis Antwerpen
StadAntwerpen
Auteur 4
Naamde Keizer
InitialenRJ
InstituutUniversitair Ziekenhuis Antwerpen en Leiden University Medical Center
StadAntwerpen
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