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Deze abstract is toegekend aan sessie SBO-BOG Free papers: Tumoren/Tumeurs
TitelIodine 125 plaque radiotherapy for uveal melanoma with thickness greater than 8 mm
DoelTo evaluate tumor control and treatment complications following Iodine 125 plaque radiotherapy (IPR) for large choroidal melanoma.
MethodesProspective observational case series.
77 patients with uveal melanoma with thickness greater than 8 mm.
All patients underwent IPR (median dose to tumor apex, 90 Gy) according to a standard protocol.
Follow-up ocular and systemic evaluations were performed every 6 months.
ResultatenThe median tumor diameter and thickness were 15.7 mm (range, 10 to 22) and 9.4 mm (range, 8 to 15).
After a mean follow-up of 43 months, local tumor recurrence was clinically documented in one patient (1%) and neovascular glaucoma in 18 patients (23%). Late enucleation was performed in 6 cases (8 %) after a mean interval of 35 months after IPR. Kaplan-Meier estimate for neovascular glaucoma was 4% at 1 year, 30 % at 3 years and 40% at 5 years, and was 0% at 1 year, 8 % at 3 years and 20% at 5 years for late enucleation. Systemic metastatic disease was documented in 17 patients (22%) after a mean interval of 26 months after IPR. The Kaplan Meier estimate for melanoma-specific death was 30% at 5 years .
ConclusieIPR seems to be a reasonable alternative to primary enucleation by providing a fair chance of preserving the eye of those patients with large uveal melanomas who have a poor systemic prognosis with short survival. This information can be used to counsel patients with large uveal melanoma traditionally managed with primary enucleation.
Auteur 1
NaamVERTES
InitialenD
InstituutOcular Oncology Unit, Cliniques Universitaires St-Luc, UCL
StadBruxelles
Auteur 2
NaamDE POTTER
InitialenP
InstituutOcular Oncology Unit, Cliniques Universitaires St-Luc, UCL
StadBruxelles
Auteur 3
NaamJAMART
InitialenJ
InstituutCliniques Universitaires de Mont Godinne
StadYvoir
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