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Deze abstract is toegekend aan sessie OB Free papers: Glaucoma
TitelMicroplasmin improves surgical outcome in a rabbit model for trabeculectomy
Abstract Nr.322
DoelThis study was designed to study the efficacy and safety of Microplasmin as an anti-scarring agent after trabeculectomy in a rabbit model.
MethodesThe effect of Microplasmin was investigated in vivo in a rabbit model for glaucoma surgery. Clinical outcome measures were intra-ocular pressure, bleb area and survival, side effects on slit lamp examination. Moreover, (immuno-) histochemical analysis of the eyes was performed, with quantification of inflammation (CD 45) and collagen deposition (Trichrome and Sirius Red).
In the first experiment (n=10), Microplasmin anterior chamber injection was compared to placebo injection. In the second experiment (n=3), topical Microplasmin drops were compared to placebo drops. In the third experiment (n=5) the combination of Microplasmin anterior chamber injection and topical drops was compared to placebo injection and drops. All experiments were conducted in a masked observator way.
ResultatenMicroplasmin augmented the bleb area and survival in a rabbit model of trabeculectomy after a single anterior chamber injection or combination therapy (injection combined with drops) compared to control. Collagen deposition was borderline reduced after Microplasmin administration compared to control. No significant changes in inflammation were noticed in the anterior chamber or in the conjunctiva.
ConclusieMicroplasmin single injection or combination with postoperative drops improved the outcome after trabeculectomy. In a rabbit model, larger blebs were produced for a longer period compared to control, and collagen deposition tended to decrease in this small series.
Auteur 1
NaamVANDEWALLE
InitialenE
InstituutLab of Ophthalmology
StadLeuven
Auteur 2
NaamVan Bergen
InitialenT
InstituutLab of Ophthalmology
StadLeuven
Auteur 3
NaamVan de Veire
InitialenS
InstituutLab of Ophthalmology
StadLeuven
Auteur 4
NaamMoons
InitialenL
InstituutDept of Animal Physiology and Neurobiology
StadLeuven
Auteur 5
NaamStalmans
InitialenI
InstituutLab of Ophthalmology
StadLeuven
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