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TitelOcriplasmin is particularly efficacious in specific types of vitreomacular traction and can induce transient ultrastructural changes at the optic disc
Abstract Nr.1065
DoelTo determine the efficacy and safety of ocriplasmin for vitreomacular traction (VMT) release in specific indications, and to study changes in optic disc and peripapillary region.
MethodesRetrospective, single-center, observational case series. In 38 eyes with VMT (of which 10 had concomitant MH), determined by optical coherence tomography (OCT), a single intravitreal injection of ocriplasmin was administered. Baseline characteristics included age, gender, presence of epiretinal membrane (ERM) and/or macular hole (MH), and visual acuity. Spectral domain OCT and Heidelberg retinal tomography (HRT) were performed at baseline and during follow-up visits.
ResultatenA total of 71.1% (27/38) eyes [37 patients] treated with ocriplasmin had VMT resolution with 40% (4/10) of eyes with MH at baseline (10/38) achieving MH closure. 90% (9/10) of eyes with MH at baseline showed VMT release. 36.8% (14/38) had increased subretinal fluid (SRF) that resolved concurrently with posterior vitreous detachment (PVD) in 12 patients, with partial PVD in 1 patient, and no PVD in the latter. There was also SRF accumulation in the peripapillary region in 21.4% (3/14) of patients with SRF in the macular region that largely resolved spontaneously by 1 month
ConclusieOcriplasmin is a novel treatment for patients with VMT. Careful patient selection can improve ocriplasmin efficacy and will aid clinical decision making. Transient optic disc changes after its use are possible.
Auteur 1
NaamWILLEKENS
InitialenKW
InstituutUZ Leuven - Dpt Oftalmologie
StadLeuven
Auteur 2
NaamAbegão Pinto
InitialenLAP
InstituutInstitute of Pharmacology and Neurosciences, Faculty of Medicine of Lisbon University, Lisbon, Portu
StadLisbon
Auteur 3
NaamVandewalle
InitialenEV
InstituutUZ Leuven
StadLeuven
Auteur 4
NaamStalmans
InitialenIS
InstituutUZ Leuven
StadLeuven
Auteur 5
NaamStalmans
InitialenPS
InstituutUZ Leuven
StadLeuven
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