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TitelUse of retinal oximetry in estimating cerebral tissue oxygenation
Abstract Nr.1062
DoelTo investigate the correlation between cerebral tissue oxygenation (SctO2) and retinal vessel oxygen saturation (SO2) using non-invasive spectroscopy in healthy individuals.
MethodesRetinal and cerebral oxygen saturations were measured in healthy volunteers using dual wavelength retinal oximetry and transcranial near-infrared spectroscopy (NIRS) respectively. Correlations between SO2 and SctO2 were analyzed using Pearson correlation coefficients. Multivariate analysis was performed to determine the relative contribution of the arterial and venous vessels to SctO2. Using this model, SctO2 was estimated based on retinal arterial and venous oxygen saturation. The measured and the predicted SctO2 were compared using Pearson correlation coefficients, paired sample t-test and Bland-Altman analysis.
ResultatenTwenty-one young healthy individuals aged 26.4±2.2 years were analyzed. SctO2 showed a significant positive correlation with both arterial and venous SO2 (r=0.442, P=0.045 and r=0.434 P=0.049 respectively). In multivariate analysis, the relative contribution of arterial and venous SO2 to SctO2 was significantly correlated with diastolic blood pressure, retinal venous oxygen saturation and retinal venous diameter (R2=0.60, P<0.001).
The measured SctO2 (72.2±3.5%, range 67.3–80.1) correlated well with estimated SctO2 (72.2±2.6%, range 67.6–77.5) (r=0.774, P<0.001). Bland–Altman plots showed 95% agreement within ±6.8%.
ConclusieIn this pilot study, retinal oximetry showed promising as an estimate of cerebral tissue oxygenation as measured by NIRS.
Auteur 1
NaamVAN KEER
InitialenK
InstituutUZ Leuven
StadLeuven
Auteur 2
NaamAbegão Pinto
InitialenL
InstituutFaculty of Medicine of Lisbon University
StadLisbon
Auteur 3
NaamStalmans
InitialenI
InstituutUZ Leuven
StadLeuven
Auteur 4
NaamVandewalle
InitialenE
InstituutUZ Leuven
StadLeuven
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