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Deze abstract is toegekend aan sessie BOG-SBO: Chirurgisch netvlies / Retine chirurgicale
TitelThe use of microplasmin in vitreoretinal surgery: a phase II clinical trial
Abstract Nr.184
DoelEnzymatic induction of a posterior vitreous detachment may be beneficial in enhancing vitrectomy for vitreomacular interface disorders. At present, only autologous plasmin is known to be a relative safe drug for this purpose. However, isolation of this enzyme is a tedious process and is not standardized.
Microplasmin is a recombinant enzyme derived from human plasmin. The aim of this phase II multi-centric study is to evaluate the clinical use and possible side-effects of microplasmin injected intravitreally before vitrectomy.
Methodes60 patients will be included with vitreomacular traction (idiopathic or diabetic) or macular hole (stages II or III). The drug is injected in variable dosage and at different time intervals before the surgery (6 cohorts). Clinical results and possible side-effects are evaluated before the surgery and up to 6 months after the surgery using ophthalmic examination, funduscopy, angiography, electrophysiology and OCT.
ResultatenAt present, 16 patients are included in the study. No serious side effects related to the injected microplasmin have been reported.
Auteur 1
NaamSTALMANS
InitialenP
InstituutUZLeuven
StadLeuven
Auteur 2
NaamFeron
InitialenE
InstituutEye Hospital Rotterdam
StadRotterdam, The Netherlands
Auteur 3
NaamGandorfer
InitialenA
InstituutDept of Ophthalmology, Ludwig Maximilians University
StadMunich, Germany
Auteur 4
NaamKampik
InitialenA
InstituutDept of Ophthalmology, Ludwig Maximilians University
StadMunich, Germany
Auteur 5
NaamDe Smet
InitialenMD
InstituutAcademic Medical Center
StadAmsterdam, The Netherlands
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