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Cet abstract a été assigné à session SB0-BOG Free paper: Glaucoma/Glaucome
TitreHaptoglobin knockout mice exhibit morhologic changes consistent with iridocorneal dysgenesis and glaucoma
Abstract Nr.217
ButTo investigate the ocular phenotype of mice that lack the acute phase protein Haptoglobin (Hpko).
MéthodesHpko mice were clinically evaluated at 3, 8 and 16 weeks of age, eye pressure was measured at 3 and 8 weeks. Mice that showed macroscopic changes of the eyes were sacrificed and their eyes were enucleated, fixed in paraformaldehyde, histologically sectioned and stained with hematoxylin and eosin. The diameter of the eye was measured and the histomorphology was evaluated and compared with eyes of normal wild-type mice.
RésultatsClinical observation revealed that between 10 and 20 % of the Hpko mice exhibited gradual opacification of the cornea and shrinkage of the eyes. These mice were investigated. The eyes of Hpko mice were between 10 and 40 % smaller than eyes of normal mice. The eyes of Hpko mice showed rudimentary and more widely spread processi of the ciliary body. Moreover the anterior chamber showed goniosynechia and irido-corneal adhesions, as well as attenuation the trabecular meshwork. The neuroretina showed a variable atrophy in ganglion cell layers in all all Hpko mice and in the inner nuclear and plexiform layer in 80 %.
ConclusionHaptoglobin knockout mice have structural abnormalities of the anterior segment and neuroretina comparable to human iridocorneal dysgenesis and developmental glaucoma.
Auteur 1
NomVAN GINDERDEUREN
InitialesR
InstitutOogziekten UZ Leuven
VilleLeuven
Auteur 2
NomGalicias-Rosas
InitialesG
InstitutImmunology
VilleLeuven
Auteur 3
NomVandeveire
InitialesS
InstitutOogziekten
VilleLeuven
Auteur 4
NomVan Bergen
InitialesT
InstitutOogziekten
VilleLeuven
Auteur 5
NomVan Schelvergem
InitialesK
InstitutOogziekten
VilleLeuven
Auteur 6
NomCeuppens
InitialesJ
InstitutImmunology
VilleLeuven
Auteur 7
NomStalmans
InitialesI
InstitutOogziekten
VilleLeuven
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