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Cet abstract a été assigné à session SBO-BOG Free papers: Chirurgie retina en vitreum/chirurgie rétine et vitré
TitreEnzymatic vitreolysis with µplasmin: a new tool in the vitreoretinal surgery?
Abstract Nr.131
ButSeveral vitreoretinal diseases are caused or enhanced by traction of the posterior vitreous membrane on the macular area, such as: vitreomacular traction syndrome, idiopathic macular hole formation, diabetic retinopathy and even age related macular degeneration.
At present, several clinical studies are being performed to evaluate the safety and efficacy of microplasmin to induce a posterior vitreous detachment, avoiding the need to perform a vitrectomy in these patients.
MéthodesPatients are randomized to different doses of microplasmin intravitreal injection or a placebo injection (not administered intravitreally).
Vitreomacular traction is evaluated at baseline and at several timepoints after administration of the study drug by a masked observer using slit lamp examination, ophthalmoscopy, optical coherence tomography (OCT) and B-scan ultrasound.
RésultatsAt present, injection of microplasmin intravitreally is well tolerated, and is capable of inducing a posterior vitreous detachment in several included patients.
ConclusionAlthough clinical studies are far from completed, it seems that microplasmin may become a valuable tool for the vitreoretinal specialist in the treatment of several eye diseases related to vitreomacular traction.
Auteur 1
NomSTALMANS
InitialesP
InstitutDept. Ophthalmology UZLeuven
VilleLeuven
Auteur 2
NomVAN CALSTER
InitialesJ
InstitutDept. Ophthalmology UZLeuven
VilleLeuven
Auteur 3
NomVAN AKEN
InitialesE
InstitutUZGent
VilleGent
Auteur 4
NomDELAEY
InitialesC
InstitutUZGent
VilleGent
Auteur 5
NomDE SMET
InitialesMD
InstitutMiddelheim Hospital
VilleAntwerp
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