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Cet abstract a été assigné à session BSCRS: Belgian Societies of Cataract and Refractive Surgery
TitreCrosslinking for keratoconus in Down syndrome
Abstract Nr.348
ButTo report on 2 cases of Down syndrome with progressive keratoconus who underwent bilateral simultaneous crosslinking therapy.
MéthodesTwo male Down syndrome patients of 17 and 20 years old, were diagnosed with progressive keratoconus. Crosslinking therapy was performed to stabilize the cone: after removing the epithelium, application of riboflavin 0,1% solution was performed followed by ultraviolet-A 365 nm light exposure for 30 minutes under general anesthesia.
RésultatsIn the 20 year-old patient both eyes were instilled with hypoosmolar riboflavin solution to achieve swelling of the cornea because of thin corneas on pachymetry. Only one eye was exposed to UV-A light because of the lack of swelling and pachymetry of less than 300µ of the other cornea. Follow-up time was 6 months. Stabilisation in the treated eye could be shown for a follow up period of more than one year.
In the other patient standard crosslinking was performed in both eyes. Two days post-crosslinking a corneal ulcus was found in the right eye and intensive antibiotic treatment was applied. A temporary tarsoraphy was necessary because of uncontrollable rubbing of the eye; the patient had to be sedated to allow for examination and treatment of the ulcer. After 4 months of follow-up a paracentral scar persists, while the other eye healed uneventfully.
ConclusionKeratoconus has been found to be frequently associated with Down syndrome.
Progressive keratoconus in patients with Down syndrome can be a good indication for crosslinking to avoid corneal transplant. However follow up and treatment of these patients can be more challenging as the ability to co-operate can vary very much for individuals with Down syndrome.
Auteur 1
NomLEYSEN
InitialesI
InstitutUZA
VilleAntwerp
Auteur 2
NomKOPPEN
InitialesC
InstitutUZA
VilleAntwerp
Auteur 3
NomDE VEUSTER
InitialesI
InstitutUZA
VilleAntwerp
Auteur 4
NomTASSIGNON
InitialesMJ
InstitutUZA
VilleAntwerp
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