View abstract

Cet abstract a été assigné à session AOB Free papers
TitreTopical ciclosporin in the treatment of vernal keratoconjunctivitis in Rwanda, Central Africa: a randomised, double-masked, controlled clinical trial
ButTo compare the short-term efficacy and safety of topical ciclosporin A (CsA) 2% with dexamethasone 0.1% in the treatment of predominantly limbal VKC in Rwanda.
MéthodesConsecutive patients with VKC were randomised in a prospective, double-masked, clinical trial to receive either topical CsA 2% dissolved in olive oil vehicle or dexamethasone 0.1% drops for 4 weeks. Both groups then received sodium chromoglycate 2% drops for maintenance therapy for a further 4 weeks. The primary outcome was the reduction in composite score for VKC-related symptoms and signs at 4 weeks. Secondary outcomes included side effects, comfort rating of the trial drops during 4 weeks test medication, and relapse rate thereafter.
RésultatsThe 366 participants recruited had the limbal (91.5%) or mixed form of VKC. At the end of the 4 week treatment period the composite score had significantly (p<0.001) reduced from baseline without a significant difference between CsA and dexamethasone (p= 0.20).There were no severe adverse reactions but CsA drops caused more stinging than the oil placebo and dexamethasone (p<0.001). The relapse rate following cessation of the trial treatments was similar (p= 0.84) in both groups.
ConclusionThere is no significant difference between the efficacy of topical CsA 2% and dexamethasone 0.1% for the management of acute VKC in Central Africa, but tolerance needs to be improved.
Auteur 1
NomDE SMEDT
InitialesSK
InstitutOphthalmology Department, Ghent University Hospital
VilleGent
Auteur 2
NomNKURIKIYE
InitialesJ
InstitutOphthalmology Department, King Faisal Hospital
VilleKigali, Rwanda
Auteur 3
NomFONTEYNE
InitialesY
Institut Kabgayi Hospital
VilleMuhanga, Rwanda
Auteur 4
NomTUFT
InitialesS
InstitutMoorfields Eye Hospital NHS Foundation Trust
VilleLondon, UK
Auteur 5
NomDE BACQUER
InitialesD
InstitutPublic Health Department, Ghent University Hospital
VilleGent
Auteur 6
NomGILBERT
InitialesC
InstitutInternational Centre for Eye Health
VilleLondon, UK
Auteur 7
NomKESTELYN
InitialesP
InstitutOphthalmology Department, Ghent University Hospital
VilleGent
top ^