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Cet abstract a été assigné à session BOG-SBO: Chirurgisch netvlies / Retine chirurgicale
Titre5-FU is systemically absorbed after intraocular infusion during vitrectomy
Abstract Nr.179
ButTo determine whether 5-fluorouracil (5-FU) used in infusion fluid during vitrectomy is systemically absorbed.
MéthodesTwo patients underwent pars plana vitrectomy, using 5-FU in the intraocular infusion during surgery. Urine samples were collected until 72 hours after the surgery. Urinary concentrations of a-fluoro-b-alanine (FBAL), the major excretion product of 5-FU, were determined by gas chromatography-mass spectrometric analysis (GC-MSMS).
RésultatsThe highest concentrations and total amount of FBAL were found during the first 6 hours after surgery. The concentration and total amount of FBAL was higher in the patient who received silicone oil tamponade (versus 17.5% SF6), with the longest surgery time (40 minutes versus 20 minutes) and the highest amount of infusion fluid used (350 ml versus 250 ml). In neither patient FBAL could be found in the urine collected after 72 hours.
Conclusion5-FU is systemically absorbed when used in infusion fluid during vitrectomy. FBAL is measured in variable concentrations and excreted in the urine till 48 hours after vitrectomy, with the highest amounts the first 6 hours after surgery. Further studies will be needed to determine which clinical settings influence the absorption. Since only small amounts of 5-FU are systemically absorbed after intravitreal application compared to IV administration, though not negligible, the risk of side effects of intravitreal 5-FU administration is small. Nevertheless, patient selection is needed to avoid adverse effects on procreativity.
Auteur 1
NomCRETEN
InitialesO
InstitutUZLeuven
VilleLeuven
Auteur 2
NomStalmans
InitialesP
InstitutUZLeuven
VilleLeuven
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