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Titre	Functional outcomes after radiotherapy in patients with progressive skull base meningioma
Abstract Nr.	P03

But	To study visual and oculomotor outcome as well as putative complications after 3D conformal radiotherapy in patients with progressive skull base or optic nerve sheath meningioma.
Méthodes	We reviewed 29 patients with a mean age of 56.7 years. Twenty-five patients had sellar and parasellar meningiomas: 11 with orbital extension; 4 patients had optic nerve sheath meningioma with intracranial involvement (3unilateral, 1bilateral). At diagnosis, 26 patients had visual loss, 13 patients had associated oculomotor palsy. Three patients had isolated oculomotor palsy, with V nerve neuralgia in 2. Before radiotherapy,19 patients had partial surgical resection, 10 others only radiotherapy. A total dose of 54 Gy in 30 fractions was delivered using a 3D conformal radiation technique.
Résultats	The mean follow-up was 34 months (4-72): 6/26 patients had visual improvement (of 0.1-0.6), 5/29 pts improved oculomotor or trigeminal disturbances. In 18 patients, vision and oculomotor palsy were stabilized. Two patients had clinical and radiographic progression 3 to 4 years after radiation therapy. In 25/29 patients, annual MRI follow-up did not show any tumor modification. None of the patient developed optic nerve or brain radionecrosis. Twenty-four patients had an endocrinological follow-up: 5 had directly a pan-hypopituitarism, 6 a pituitary deficiency, at a mean time of 26 mo. after radiotherapy.
Conclusion	Our series confirms the beneficial effect of radiotherapy combined or not with surgery in meningioma involving anterior visual pathway and oculomotor nerves: local tumor control in 93% and clinical improvement in 38% of the patients.

Auteur 1

Nom	BOSCHI
Initiales	A
Institut	Dept of Ophthalmology

Auteur 2

Nom	Renard
Initiales	L
Institut	Radiation Oncology

Auteur 3

Nom	Raftopoulos
Initiales	Ch
Institut	Neurosurgery

Auteur 4

Nom	Maiter
Initiales	D
Institut	Endocrinology

Auteur 5

Nom	Cosnard
Initiales	G
Institut	Neuroradiology

Auteur 6

Nom	De Potter
Initiales	P
Institut	Ophthalmology Clin Univ St LUc
Ville	Bruxelles