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Cet abstract a été assigné à session BOG-SBO: Glaucoma / Glaucome
TitreOptic disc hemorrhages and progression to glaucoma in the European Glaucoma Prevention Study (EGPS)
Abstract Nr.171
ButTo determine the predictive value of optic disc hemorrhages (ODHs) for the development of glaucoma.
MéthodesThe European Glaucoma Prevention Study was designed to evaluate whether reducing the intra-ocular pressure in patients with ocular hypertension might reduce the risk of progression to glaucoma. All eyes included in the EGPS study were monitored for optic disc hemorrhages (ODHs) every 6 months for 5 years both by fundoscopy and evaluation of optic disc stereo-photographs. Chi-square test was used to compare the rates of progression
Résultats1923 eyes of 1081 participants were analyzed. Thirty-three eyes (1.7%) developed ODHs on at least one occasion. The total percentage of eyes that developed glaucoma was 6,1% (117 out of 1923 eyes). Of patients that developed glaucoma, 18.2% (6 out of 33) had a previous ODH, whereas 5.9% (111 out of 1890) did not have a history of ODH (p=0.0127 by Fisher Exact test). Using a Cox Regression test with time-varying covariate, taking into account both the differences in follow-up and the moment of occurrence of the ODH between the patients, the hazard ratio for the first occurrence of ODH was 4.55 (p=0.001). Finally, to overcome the problem of clustering of the eyes within a patient, and the presence of interval-censoring, a hazard ratio was calculated for each of the 10.000 non-parametric bootstrap samples. The mean hazard ratio was still 3.97, although this relation was only borderline significant (p=0.06).
ConclusionThese results indicate that optic disc hemorrhages are associated with an increased risk of conversion to glaucoma.
Auteur 1
NomSTALMANS
InitialesI
InstitutUZ Leuven
VilleLeuven
Auteur 2
NomZEYEN
InitialesT
InstitutUZ Leuven
VilleLeuven
Auteur 3
NomMIGLIOR
InitialesS
InstitutUniversita Milano Biccocca
VilleMonza
Auteur 4
NomPFEIFFER
InitialesN
InstitutMeinz University
VilleMeinz
Auteur 5
NomCUNHA-VAZ
InitialesJ
InstitutAzinhaga Santa Combra
VilleCoimbra
Auteur 6
NomADAMSONS
InitialesI
InstitutLafayette Hill
VilleLafayette Hill, PA
Auteur 7
NomEGPS study group
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