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TitelRetinal oxygen metabolism in healthy subjects and glaucoma patients
DoelTo study the role of ischemia/hypoxia in the pathophysiology of glaucoma in a prospective, clinical trial.
MethodesThis was a 2 centre study where retinal vessel oxygen saturation was measured in glaucoma patients and healthy individuals with a non-invasive spectrophotometric retinal oximeter. Visual fields were obtained in the glaucoma patients. Statistical analysis was performed using a Student’s t-test.
ResultatenNo statistical difference was found in retinal oxygen saturation in arterioles (p=0.16), in venules (p=0.12) and arteriovenous difference (AV) (p=0.39) whenglaucoma patients (n=74) were compared to healthy individuals (n=89). However, when patients with advanced glaucoma (visual field mean defect (MD≤-10dB, n=21) were compared to healthy individuals, the oxygen saturation in venules was higher (58%±5% vs. 54%±6%; p=0.005, mean ± standard deviation (SD)) and the AV difference was lower (36±5% vs. 40%±6%; p=0.02). In glaucoma patients with mild glaucoma (MD≥-5dB, n=33), compared to healthy individuals, no statistical differences were found in retinal oxygen saturation (p=0.26-0.99).
ConclusieGlaucoma patients with severe glaucoma have higher oxygen saturation in venules and lower AV difference in oxygen saturation compared to healthy individuals. No difference is found between healthy individuals and glaucoma patients with mild visual field defects. The decreased AV difference in severe glaucoma may be related to lower oxygen consumption resulting from tissue atrophy in the retina.
Auteur 1
NaamVANDEWALLE
InitialenE
InstituutUZLeuven
StadLeuven
Auteur 2
NaamOlafsdottir
InitialenOB
InstituutUniversity of Iceland
StadReykjavik
Auteur 3
NaamPinto
InitialenLA
InstituutLisbon University
StadLisbon
Auteur 4
NaamStalmans
InitialenP
InstituutUZLeuven
StadLeuven
Auteur 5
NaamVan Calster
InitialenJ
InstituutUZLeuven
StadLeuven
Auteur 6
NaamZeyen
InitialenT
InstituutUZLeuven
StadLeuven
Auteur 7
NaamStefánsson
InitialenE
InstituutUniversity of Iceland
StadReykjavik
Auteur 8
NaamStalmans
InitialenI
InstituutUZLeuven
StadLeuven
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