View abstract

Cet abstract a été assigné à session Poster session in O'Bistro

Titre

Retinal oxygen metabolism in healthy subjects and glaucoma patients

But	To study the role of ischemia/hypoxia in the pathophysiology of glaucoma in a prospective, clinical trial.
Méthodes	This was a 2 centre study where retinal vessel oxygen saturation was measured in glaucoma patients and healthy individuals with a non-invasive spectrophotometric retinal oximeter. Visual fields were obtained in the glaucoma patients. Statistical analysis was performed using a Student’s t-test.
Résultats	No statistical difference was found in retinal oxygen saturation in arterioles (p=0.16), in venules (p=0.12) and arteriovenous difference (AV) (p=0.39) whenglaucoma patients (n=74) were compared to healthy individuals (n=89). However, when patients with advanced glaucoma (visual field mean defect (MD≤-10dB, n=21) were compared to healthy individuals, the oxygen saturation in venules was higher (58%±5% vs. 54%±6%; p=0.005, mean ± standard deviation (SD)) and the AV difference was lower (36±5% vs. 40%±6%; p=0.02). In glaucoma patients with mild glaucoma (MD≥-5dB, n=33), compared to healthy individuals, no statistical differences were found in retinal oxygen saturation (p=0.26-0.99).
Conclusion	Glaucoma patients with severe glaucoma have higher oxygen saturation in venules and lower AV difference in oxygen saturation compared to healthy individuals. No difference is found between healthy individuals and glaucoma patients with mild visual field defects. The decreased AV difference in severe glaucoma may be related to lower oxygen consumption resulting from tissue atrophy in the retina.

Auteur 1

Nom	VANDEWALLE
Initiales	E
Institut	UZLeuven
Ville	Leuven

Auteur 2

Nom	Olafsdottir
Initiales	OB
Institut	University of Iceland
Ville	Reykjavik

Auteur 3

Nom	Pinto
Initiales	LA
Institut	Lisbon University
Ville	Lisbon

Auteur 4

Nom	Stalmans
Initiales	P
Institut	UZLeuven
Ville	Leuven

Auteur 5

Nom	Van Calster
Initiales	J
Institut	UZLeuven
Ville	Leuven

Auteur 6

Nom	Zeyen
Initiales	T
Institut	UZLeuven
Ville	Leuven

Auteur 7

Nom	Stefánsson
Initiales	E
Institut	University of Iceland
Ville	Reykjavik

Auteur 8

Nom	Stalmans
Initiales	I
Institut	UZLeuven
Ville	Leuven