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TitelThe effect of AMA0076, a locally acting rho kinase (ROCK) inhibitor, on IOP in Dutch Belted Rabbits
DoelTo determine the intra ocular pressure (IOP) lowering efficacy of the local ROCK inhibitor, AMA0076, in Dutch Belted rabbits.
MethodesDutch Belted rabbits (5 rabbits/group) received topically a single dose of AMA0076 in one eye. A concentration range of 0.031 - 0.625% AMA0076 was tested. The contralateral eye served as control and was treated with saline. IOP was measured at baseline and 30 min, 1, 2, 3, 4, 5, 6, 7, 8h post topical administration.
ResultatenSingle topical administration of AMA0076 significantly lowered IOP in all groups compared to the control eye (p<0.05). Mean baseline IOP during the experiments was between 20.6 and 21.5 mmHg. Thirty minutes after topical treatment, a concentration dependent reduction in IOP was demonstrated with a ΔIOP ranging from 3.9mmHg – 7mmHg compared to the control eye. Maximal IOP reduction of each concentration following single dose administration of AMA0076 was observed ±2 hours after instillation with a ΔIOP ranging from 4.6mmHg and 7.5mmHg. The IOP lowering effect with the highest concentrations of AMA0076 (0.625% and 0.125%) was sustained during the experiment.
ConclusieAMA0076 was effective in rapidly lowering IOP in a dose depended and sustained manner after a single topical dose in Dutch Belted rabbits. This new class of local ROCK inhibitors has potential therapeutic value for the IOP lowering treatment of glaucoma.
Auteur 1
NaamVAN DE VELDE
InitialenS
InstituutUniversiteit Leuven
StadLeuven
Auteur 2
NaamVan Bergen
InitialenT
InstituutUniversiteit Leuven
StadLeuven
Auteur 3
NaamSijnave
InitialenD
InstituutUniversiteit Leuven
StadLeuven
Auteur 4
NaamHollanders
InitialenK
InstituutUniversiteit Leuven
StadLeuven
Auteur 5
NaamVandewalle
InitialenE
InstituutUniversiteit Leuven
StadLeuven
Auteur 6
NaamMoons
InitialenL
InstituutUniversiteit Leuven
StadLeuven
Auteur 7
NaamLeysen
InitialenD
InstituutAmakem NV
StadDiepenbeek
Auteur 8
NaamStalmans
InitialenI
InstituutUniversiteit Leuven
StadLeuven
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