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TitelReduction of macular cysts after treatment with topical Dorzolamide in X-Linked Retinoschisis: A case report
DoelTo document the effects of Dorzolamide treatment on a 4 year old boy with X-linked retinoschisis (XLRS) by optical coherence tomography.
MethodesXLRS is an inherited retinal disease which affects young boys. It is characterized by bilateral cystoid macular changes and a peripheriral retinoschisis in 50% of patients. During a number of decades, the ERG was the best diagnostic tool, showing a marked decrease in amplitude of the b-wave with a normal a-wave on scotopic and photopic testings. However, the recent use of the optical coherence tomography has allowed an easier follow-up of maculopathy. Overall, molecular research of mutations provides the final confirmation.
ResultatenWe report a significant reduction of macular cysts after a few months of local instillation of Dorzolamide.
ConclusieXLRS is one of the most frequent cause of early-onset macular degeneration in males. No successful treatment has yet been reported and the ophthalmologist was for a long time limited to the prescription of low vision aids and surgical management of complications such as vitreous hemorrhage and retinal detachement. Although gene therapy in mice led to promising results by restoring retinal function, further studies are still required.
Nevertheless, recent studies show a significant reduction of the macular schisis when applying carbonic anhydrase inhibitor locally. Our case report illustrates this statement.
Auteur 1
NaamVAN BOL
InitialenL
InstituutErasme
StadBruxelles
Auteur 2
NaamDepasse
InitialenF
InstituutErasme
StadBruxelles
Auteur 3
NaamCordonnier
InitialenM
InstituutErasme
StadBruxelles
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