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TitreHyperspectral imaging and the retina: worth the wave?
ButHyperspectral imaging is gaining attention in biomedical research because it generates additional spectral information that can be used to study physiological and clinical processes. Several methods have been described, but an independent, systematic literature overview is lacking, especially in the field of ophthalmology.
MéthodesA literature search has been conducted, following the PRISMA Statement 2009 criteria, in four large bibliographic databases. Articles have been included based upon their relevance. Wherever possible, risk of bias and quality have been assessed.
RésultatsFifty-two articles have been withheld. Seven studies have been assessed by means of Newcastle-Ottawa Quality Assessment Scale (NOS), while Techniques based on Fourier analysis, liquid crystal tunable filters, tunable laser sources, dual-slit monochromators, dispersive prisms and gratings, computed tomography, fiber optics and Fabry-Perrot cavity filter covered complementary metal oxide semiconductor (CMOS) are being reported, all with variable acquisition time, spectral width, spectral and spatial resolution and experimental set-up. We performed a narrative synthesis and produced summary tables of findings of included papers because methodological heterogeneity and research topic precluded a meta-analysis.
ConclusionThe application in ophthalmology is still in its infancy. Most of the experiments have been performed in the field of retinal oximetry. Relatively small studies show promising results for hyperspectral imaging, e.g. in Alzheimer research. The true potential of this innovative technique remains to be unlocked.
Conflit d'intérêtNon
Auteur 1
NomVAN EIJGEN
InitialesJ
InstitutUZ Leuven/KU Leuven
VilleLeuven
Auteur 2
NomLemmens
InitialesS
InstitutUZ Leuven/KU Leuven/VITO
VilleLeuven
Auteur 3
NomVan Keer
InitialesK
InstitutUZ Leuven/KU Leuven
VilleLeuven
Auteur 4
NomDe Boever
InitialesP
InstitutVITO
VilleMol
Auteur 5
NomStalmans
InitialesI
InstitutUZ Leuven/KU Leuven
VilleLeuven
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