Title | Clinical impact of 18F-FDG PET CT in the work up of children with uveitis. |
Purpose | To evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) in the work up of paediatric uveitis. |
Methods | We performed a retrospective study of 12 children followed for uveitis who underwent whole body 18F-FDG PET/ultra low dose CT between 2011 and 2019. |
Results | The average patients’ age was 11 years. 100% of patients presented bilateral uveitis, 50% panuveitis and 92% (11/12) had choroidal involvement. 5 of the 12 (42%) patients showed abnormal 18F-FDG uptake on their 18F-FDG PET/CT, including 3 with pathognomonic images of active granulomatous diseases. A biopsy was performed in one of these patients (consistent with sarcoidosis) and in the two others with abnormal 18F-FDG uptake without pathognomonic images of granulomatous disease (one consistent with sarcoidosis, the other negative). Final uveitis diagnosis were idiopathic in 58% of the patients, ocular sarcoidosis in 17% (2/12), TINU in 16,6% (2/12) and tubercular uveitis in 8,3% (1/12). |
Conclusion | In this small series, 18F-FDG PET/CT provided important information for uveitis diagnosis in approximatively 30 % (4/12) of our patients. Further studies are needed to define the exact place of 18F-FDG PET/CT and chest CT in the work-up of paediatric uveitis. |
Conflict of interest | No |
Last name | EL MOUDEN |
Initials | J |
Department | Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB |
City | Bruxelles |
Last name | Bazewicz |
Initials | M |
Department | Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB |
City | Bruxelles |
Last name | Makhoul |
Initials | D |
Department | Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB |
City | Bruxelles |
Last name | Goffin |
Initials | L |
Department | Pediatric Immuno-Rheumatology - CHU HUDERF - ULB |
City | Bruxelles |
Last name | Judice |
Initials | L |
Department | Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB |
City | Bruxelles |
Last name | Caspers |
Initials | L |
Department | Ophthalmology - CHU St-Pierre - ULB |
City | Bruxelles |
Last name | Draganova |
Initials | D |
Department | Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB |
City | Bruxelles |
Last name | Garcia |
Initials | C |
Department | Nuclear Medicine - CHU St-Pierre - ULB |
City | Bruxelles |
Last name | Willermain |
Initials | F |
Department | Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB |
City | Bruxelles |