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Type presentatieOral presentation
TitelNeurotrophic keratitis: where do we stand?
DoelNeurotropic keratitis is a rare condition marked by a decreased or absent corneal sensitivity. The cornea becomes susceptible to developing persistent epithelial defects, ulcers and other complications. The management of NK aims to facilitate corneal epithelial healing and can be challenging, as presentation is often late due to the asymptomatic nature of the disease. This systematic review aims to understand the utility of insulin eye drops as a treatment for neurotrophic keratitis.
MethodesA literature search was implemented in Medline (Pubmed), Embase and Web Of Science. All published papers written in English, Spanish or Dutch from 2005 until July 2023 were included.
ResultatenThe search yielded 13 original papers. All included patients had neurotrophic epithelial defects ranging from 3,8 mm2 to 144 mm2. After treatment with topical insulin, most of the epithelial defects showed a complete epithelization. Various concentrations, ranging from 1IU/ml to 100IU/ml, and types of insulin were used. The studies also varied in the type of vehicle used in the preparation of insulin drops Two randomized controlled trials demonstrated that topical insulin drops were more effective than conventional treatment with artificial tears or autologous serum. All included studies, except of two, reported the absence of local or systemic side effects.
ConclusieTopical insulin emerges as a promising and effective treatment for neurotrophic keratitis. It promotes healing of neurotrophic epithelial defects and exhibits advantages over the current treatment options. However, further investigation is needed.
BelangenverstrengelingNee
Auteur 1
NaamWOUTERS
InitialenC
InstituutUZLeuven
StadLeuven
Auteur 2
NaamSaelens
InitialenI
InstituutUZLeuven
StadLeuven
Auteur 3
NaamDELBEKE
InitialenH
InstituutUZLeuven
StadLeuven
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