View abstract

This abstract is assigned to session SBO-BOG Posters session >> in Poster area - Foyer +1

Title

Diabetic macular edema associated with rosiglitazone use : case report

Purpose	To report the onset or worsening of diabetic macular edema associated with use of glitazone.
Methods	Case report
Results	A 61 year old woman is referred for bilateral diabetic macular edema. Her visual acuity is 20/70 in the right eye and 20/50 in the left eye. She presents a macular edema of 546 microns thickness in the right eye and 532 microns thickness in the left eye. Her diabetes and her blood pressure are well controlled. We note that the decrease in visual acuity occured when the patient began taking rosiglitazone (Avandia) 4 mg per day. Three months after replacing rosiglitazone by gliclazide (Diamicron), the visual acuity of the patient improves to 20/40 in the right eye and 20/30 in the left eye. The macular edema shows a decrease to 257 microns thickness in the right eye and 215 microns thickness in the left eye.
Conclusion	This case report illustrates the risk of new onset or worsening of a diabetic macular edema associated with rosiglitazone use. This is most likely caused by fluid retention that is described for 5-10% of the patients who benefit from this treatment. It is important to sensitize ophthalmologists, endocrinologists and general practicians to this newly detected risk associated with rosiglitazone.

Author 1

Last name	HAUTENAUVEN
Initials	F
Department	Cliniques Universitaires Saint-Luc
City	Bruxelles

Author 2

Last name	NYSSEN
Initials	V
Department	Cliniques Universitaires Saint-Luc
City	Bruxelles

Author 3

Last name	GUAGNINI
Initials	A P
Department	Cliniques Universitaires Saint-Luc
City	Bruxelles