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This abstract is assigned to session SBO-BOG Free papers: Tumoren/Tumeurs

Title

Iodine 125 plaque radiotherapy for uveal melanoma with thickness greater than 8 mm

Purpose	To evaluate tumor control and treatment complications following Iodine 125 plaque radiotherapy (IPR) for large choroidal melanoma.
Methods	Prospective observational case series. 77 patients with uveal melanoma with thickness greater than 8 mm. All patients underwent IPR (median dose to tumor apex, 90 Gy) according to a standard protocol. Follow-up ocular and systemic evaluations were performed every 6 months.
Results	The median tumor diameter and thickness were 15.7 mm (range, 10 to 22) and 9.4 mm (range, 8 to 15). After a mean follow-up of 43 months, local tumor recurrence was clinically documented in one patient (1%) and neovascular glaucoma in 18 patients (23%). Late enucleation was performed in 6 cases (8 %) after a mean interval of 35 months after IPR. Kaplan-Meier estimate for neovascular glaucoma was 4% at 1 year, 30 % at 3 years and 40% at 5 years, and was 0% at 1 year, 8 % at 3 years and 20% at 5 years for late enucleation. Systemic metastatic disease was documented in 17 patients (22%) after a mean interval of 26 months after IPR. The Kaplan Meier estimate for melanoma-specific death was 30% at 5 years .
Conclusion	IPR seems to be a reasonable alternative to primary enucleation by providing a fair chance of preserving the eye of those patients with large uveal melanomas who have a poor systemic prognosis with short survival. This information can be used to counsel patients with large uveal melanoma traditionally managed with primary enucleation.

Author 1

Last name	VERTES
Initials	D
Department	Ocular Oncology Unit, Cliniques Universitaires St-Luc, UCL
City	Bruxelles

Author 2

Last name	DE POTTER
Initials	P
Department	Ocular Oncology Unit, Cliniques Universitaires St-Luc, UCL
City	Bruxelles

Author 3

Last name	JAMART
Initials	J
Department	Cliniques Universitaires de Mont Godinne
City	Yvoir