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Title	Clinical applications of automated pupillometry in neuro-ophthalmology
Abstract Nr.	145

Purpose	Measuring pupillary dynamics is essential in neuro-ophthalmologic practice, but is subjective and investigator-dependent. We present the possibilities of the Procyon P3000, a computerized infrared pupillometer, to objectivate routinely performed flashlight investigations in distinguishing a Horner's pupil from physiological anisocoria and in testing for relative afferent pupillary defects (RAPD).
Methods	We measured pupil sizes in Horner's syndrome (n=4) in scotopic, low mesopic and high mesopic environments; analyzed the dilatation lag with dynamic pupillometry and retested after instillation of cocaine collyrium. We quantified the amount of relative afferent pupillary defects of normal (n=8) and pathological subjects (n=4) by examining the difference in average pupillary constriction amplitudes of the right versus the left eye. The 95% confidence interval of the RAPD-quantification was calculated in normal subjects (n=2).
Results	Physiological anisocoria can be differentiated objectively from Horner pupil using this pupillometer. When only a few stimulus pairs were tested, short term variability in quantifying the RAPD was high, but after 200 stimulus pairs (approximately five minutes testing time) the short time variability was less than 0.1mm.
Conclusion	Routinely performed neuro-ophthalmological pupillary tests can be quantified, analyzed and compared using dynamic pupillometry. This is helpful in the diagnostics and follow-up of neuro-ophthalmological practice.

Author 1

Last name	RENIER
Initials	S
Department	UZ Leuven
City	Brugge

Author 2

Last name	SPILEERS
Initials	W
Department	UZ Leuven
City	Leuven